VITAMINA B5 no combate ao COLESTEROL ALTO (hiperlipidemia) | VITAMIN B5 in the fight against HIGH CHOLESTEROL (hyperlipidemia)
Por causa do papel do ácido pantotênico na síntese de triglicerídeos e no metabolismo das lipoproteínas, os especialistas levantaram a hipótese de que a suplementação de ácido pantotênico pode reduzir os níveis de lipídios em pacientes com hiperlipidemia.
Vários ensaios clínicos demonstraram que a forma de ácido pantotênico conhecida como PANTETINA reduz os níveis de lipídios quando tomada em grandes quantidades, mas o ácido pantotênico em si não parece ter os mesmos efeitos.
Os resultados foram bem promissores, resultaram em:
- Diminuição do triglicerídeos
- Diminuição do colesterol total
- Diminuição da lipoproteína de baixa densidade (LDL)
- Aumento do colesterol de lipoproteína de alta densidade (HDL)
Estudos adicionais são necessários para determinar se a suplementação de pantetina tem de fato um efeito benéfico sobre a hiperlipidemia, independentemente de, e junto com, uma dieta saudável. Pesquisas também são necessárias para determinar os mecanismos dos efeitos da pantetina nos níveis de lipídios.
Ficamos na expectativa de que novidades estão por vir em breve que realmente comprove os benefícios no combate à hiperlipidemia. Logo, tratando o colesterol consequentemente o coração se beneficiará também, prevenindo de doenças cardíacas.
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Because of pantothenic acid's role in triglyceride synthesis and lipoprotein metabolism, experts have hypothesized that pantothenic acid supplementation may reduce lipid levels in patients with hyperlipidemia.
Several clinical trials have shown that the form of pantothenic acid known as PANTETINE lowers lipid levels when taken in large amounts, but pantothenic acid itself does not appear to have the same effects.
The results were very promising, resulting in:
- Decrease in triglycerides
- Decrease in total cholesterol
- Decrease in low-density lipoprotein (LDL)
- Increased high-density lipoprotein (HDL) cholesterol
Further studies are needed to determine whether panthetin supplementation does indeed have a beneficial effect on hyperlipidemia, independently of, and in conjunction with, a healthy diet. Research is also needed to determine the mechanisms of panthetin's effects on lipid levels.
We are hoping that news is coming soon that really proves the benefits in combating hyperlipidemia. Therefore, treating cholesterol consequently the heart will also benefit, preventing heart disease.
So far, we have good signs pointing to pantetin as an ally in the treatment of hyperlipidemia.
Soon, science will certainly bring us more news about the understanding and applicability of B5 in combating various pathologies.
Do not take supplementation on your own, do not medicate yourself. Look for a Nutritionist (dietician) to assess and monitor your nutritional status. The Nutritionist (dietician) will make the necessary adjustments in your diet or supplementation, as needed.
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- Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Available on: <https://www.ncbi.nlm.nih.gov/pubmed/24600231>
- U.S. Department of Health and Human Services. Pantothenic Acid. Available on: <https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/.>
- (1) Miller JW, Rucker RB. Pantothenic acid. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:375-90.
- (19) Rumberger JA, Napolitano J, Azumano I, et al. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr Res 2011;31:608-15. [PubMed abstract]
- (20) McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Research 2005;25:319-33.
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